Allele Frequency and Genotype Distribution of 9 SNPs in the Kazakh Population

2014

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DOI 10.4172/2153-0645.1000129
Data confidence 70 medium
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Abstract

The VKORC1 gene on chromosome 16 is one of the major genes associated with effective doses of coumarin anticoagulants.Many mutations are associated with a deficiency in this enzyme.The allelic variant VKORC1 c.-1639G>A determines up to 30% of the variability in warfarin dosage [3][4][5][6][7][8].