Modification of magnetic Fe3O4 nanoparticles for targeted delivery of payloads

Ilya V. Korolkov, Katarzyna Łudzik, Lana I. Lissovskaya, Alexandr V. Zibert, Arman B. Yeszhanov, Maxim Vladimirovich Zdorovets

2021

Closed access Metadata (CSL-JSON)
DOI 10.31489/2021ch1/99-108
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

The development of methods for targeted delivery of payload is a rapidly developing area of research.For this reason, iron oxide nanoparticles have potential to be used in delivery of substances by using external magnetic field. However it is necessary to develop methods of their modification, which will lead to the pos-sibility of immobilization of payloads with the required concentration for therapeutic use. In this article, supermagnetic iron oxide nanoparticles (Fe3O4) were modified with silanes such as (3-chloropropyl)-trimethoxysilane, (3-mercaptopropyl)trimethoxysilane, (3-aminopropyl)trimethoxysilane and (3-glycidyl-propyl)trimethoxysilane by reaction of polycondensation. Then carborane compound (payload) was success-fully attached on the modified nanoparticles via covalent bonding. Structure, size and element composition were studied by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Energy-dispersive X-ray spectroscopy (EDA). It was found that resulting nanoparticles contain 16.6% of bo-ron (according to EDA), and their average size is 32±9 nm (according to SEM). In vitro test using HeLa (cer-vical cancer cell) and PC-3 (prostate cancer cell) shows low cytotoxicity in concentration range of 1–200μg/ml.