Copper‐Catalyzed Reaction of Secondary Propargylamines with Ethyl Buta‐2,3‐dienoate for the Synthesis of 1,6‐Dihydropyridines

2018

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DOI 10.1002/ejoc.201801227
Data confidence 70 medium
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Abstract

A copper(I) bromide‐catalyzed reaction of A3‐coupling‐derived propargylamines with ethyl buta‐2,3‐dienoate for the fast assembly of a 1,6‐dihydropyridine core is described. The developed protocol was tested on a variety of secondary propargylamines and the possibility of a one‐pot synthesis of 1,6‐dihydropyridine through the A3‐coupling and subsequent ethyl buta‐2,3‐dienoate incorporation was investigated.