Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines

Muhammad Hasan, Anatoly A. Peshkov, Syed Anis Ali Shah, Andrey Belyaev, Chang‐Keun Lim, Shun‐Yi Wang, Vsevolod A. Peshkov

2025

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.3762/bjoc.21.74

Data confidence 70 medium

How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

A silver(I) triflate-catalyzed post-Ugi assembly of novel pyrazolo[1,5- a ][1,4]diazepine scaffolds is reported offering high yields (up to 98%) under mild conditions. The synthetic sequence involves the Ugi four-component reaction (U4CR) of pyrazole-3-carbaldehydes, primary amines, 3-substituted propiolic acids, and isocyanides, followed by a silver(I) triflate-catalyzed intramolecular heteroannulation of the resulting pyrazole-tethered propargylamides occurring in a 7- endo - dig fashion. The approach is scalable and tolerates a diverse range of substitution patterns.