Impact of probiotics and polyphenols on adults with heart failure: a systematic review and meta-analysis

Madiyar Nurgaziyev, Samat Kozhakhmetov, Zharkyn Jarmukhanov, Ayaulym Nurgaziyeva, Shynggys D. Sergazy, Argul Issilbayeva, Zhussipbek Mukhatayev, Symbat Seidulla, Aliya Sailybayeva, Makhabbat S. Bekbossynova

1 more author

Almagul R. Kushugulova

2025

Full text Open access: Gold Metadata (CSL-JSON)
DOI 10.1186/s40001-025-02538-y
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

BACKGROUND: Heart failure poses a significant health concern globally, and despite advancements in treatment, the search for additional, supportive therapeutic options remains crucial. This systematic review and meta-analysis studied the impact of probiotics and polyphenols on heart failure biomarkers, focusing on potential improvements in heart function and inflammation. METHODS: We analyzed studies published in Embase, PubMed and Cochrane library from 2012 to 2024, focusing on randomized controlled trials. Our findings are drawn from 5 studies on probiotics, involving 401 participants, and 3 studies on polyphenols with a total of 140 participants. The analysis included assessments of LVEF, hs-CRP, creatinine and NT-proBNP levels in intervention and control groups. RESULTS: The probiotics or polyphenols from the included studies did not demonstrate significant changes in the health indicators analyzed for heart failure patients compared to placebo. CONCLUSIONS: The systematic review suggested that while the concept of dietary management for heart failure is promising, further research is necessary to validate the efficacy of probiotics and polyphenols as supplementary therapies in heart failure care, by analyzing more diverse health outcomes and patient populations.