Potential applicability of polyethyleneimine PEI-coated Eu2O3 and Dy2O3 nanoparticles for contrast enhancement in computed tomography

Valentina Olifirenko, Aiganym Abduraimova, Moon Sung Kang, Iruthayapandi Selestin Raja, Bakyt Duisenbayeva, Anara Molkenova, Laura Khamkhash, Yoon‐Hwae Hwang, Dong‐Wook Han, Timur Sh. Atabaev

Nano Express, 2021

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1088/2632-959x/abe343

Data confidence 70 medium

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Abstract

Abstract Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability of polyethyleneimine (PEI)-coated Eu2O3 and Dy2O3 nanoparticles (NPs) for CT x-ray attenuation. Morphology and other physicochemical properties of prepared samples were systematically investigated using a range of characterization tools. Preliminary cytotoxicity experiments with L-929 fibroblastic cells suggested that both samples have no significant toxicity at concentrations below 100 μg ml−1. Clinical CT analysis shows that PEI@Eu2O3 NPs exhibit higher x-ray attenuation efficiency (∼8 HU mM−1) as compared to PEI@Dy2O3 NPs (∼5 HU mM−1).