MSC Secretome and EVs

Nadiar Maratovich Mussin, Amin Tamadon

2026

Full text Open access: Hybrid Metadata (CSL-JSON)
DOI 10.1007/978-3-032-36437-1_3
Data confidence 70 medium
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Abstract

This chapter focuses on the MSC secretome and its functional components, including extracellular vesicles and soluble mediators. It highlights the complexity of conditioned media and the interplay between EVs and non-vesicular factors in therapeutic outcomes. Methodological considerations, including isolation, characterization, and contamination risks, are discussed in the context of MISEV guidelines. The chapter emphasizes the importance of functional attribution and standardization in interpreting experimental findings.