In Vitro and Preclinical Evidence for MSC–EV Therapies

Nadiar M. Mussin, Amin Tamadon

2026

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DOI 10.1007/978-3-032-36437-1_8
Data confidence 70 medium
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Abstract

This chapter reviews in vitro and preclinical evidence supporting MSC–EV-based therapies across multiple organ systems. It summarizes mechanistic findings from cellular models and evaluates efficacy in animal studies, including large-animal modelsLarge–animal models. The chapter highlights key therapeutic effects such as immunomodulation, tissue repair, and metabolic regulation. Limitations related to methodological variability, dosing inconsistencies, and translational gaps are critically discussed.