The effect of pantohematogen on cellular immunity indicators in women of fertile age with iron deficiency anemia

Kairat B. Kurmangaliyev, U.M. Bakhytzhan, Farida S. Rakhimzhanova, Azhar Nikolaevna Zhexenova, E. T. Ilyassova, Saulesh S. Kurmangaliyeva

2026

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DOI 10.59598/me-2305-6053-2026-118-1-68-78
Data confidence 70 medium
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Abstract

Recent studies indicate that iron deficiency and low serum iron levels (hypoferremia) not only cause anemia but may also impair adaptive immunity and reduce the efficacy of vaccination. In recent years, the mechanisms of action of products derived from antler deer farming and their potential applications in preventive and rehabilitation programs have been actively investigated. From a therapeutic perspective, the development of complex preparations based on maral antlers, as well as plant- and mineral-derived products (biologically active supplements (BAS) is considered promising. In the context of urban living and diets dominated by processed foods, the use of BAS becomes increasingly relevant. Aim. To assess the impact of the biologically active supplement «Liquid pantogematogen» (Zaru Pfarm, Republic of Kazakhstan), on cellular immunity indicators CD4 and CD8 in women of reproductive age suffering from iron deficiency anemia. Materials and methods . The study included 66 women aged 18 to 49 years. All participants were randomly assigned to two groups: Group I (main) – 33 women; group II (control) – 33 women. The main group received the biologically active supplement «Liquid pantogematogen» at a dose of 15 ml twice daily for 14 days. The control group was advised to maintain a healthy lifestyle and adhere to a proper diet for iron deficiency anemia. On days 18-20 follow-up testing of blood parameters was performed as scheduled. Results and discussion . Examination of immune system cells in the main group revealed an increase in the total lymphocyte population CD3+ from 68.53 to 71.90. An increase was also observed in cortical thymocytes (double-positive lymphocytes) CD4+CD8+ from 1.18 to 1.96. The subpopulation of CD3+CD8+ cells rose from 36.30 to 37.96. A significant increase in T-helper cells CD3+CD4+ was noted – from 50.25 to 60.16 (p=0.001). No statistically significant differences were observed in the control group. Conclusions . Following the use of pantogematogen, the level of CD4+ T-helper cells increased from 50.3% to 60.2% (p=0.001).