Comparison of CO2 Laser and Microdebrider in the Surgical Treatment of Pediatric Recurrent Respiratory Papillomatosis: A Retrospective Analysis

Kadylova Yerkezhan, Nazym S. Sagandykova, Madina B. Baurzhan, Aigerim Mashekova, Almat Bekpan, Darkhan Autalipov, Olzhas Mukhmetov, Damir Abdrakhmanov, E. Y. K. Ng, Sayagul A. Kairgeldina

Bioengineering, 2026

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DOI 10.3390/bioengineering13060713
Data confidence 70 medium
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Abstract

Background. Recurrent respiratory papillomatosis (RRP) in children remains a pressing issue in pediatric otolaryngology, characterized by a chronic course, frequent relapses, and the need for repeat surgical interventions. The aim of this study was to evaluate whether the surgical technique used for primary removal of pediatric RRP—CO2 laser, microdebrider, or a combined approach—was associated with clinically documented recurrence and early recurrence within 12 months. Materials and Methods. A retrospective study of 53 medical records of children who underwent their first surgery for RRP between 2019 and 2023 was conducted. Three surgical approaches were used: CO2 laser, microdebrider, and a combined method. Statistical analysis was performed using Pearson’s χ2 test, and the strength of association was evaluated with Cramér’s V. Results. The most frequently used method was the CO2 laser (n = 25), followed by a microdebrider (n = 16), and a combined method (n = 12). During the observation period, disease recurrence was recorded in 35 of 53 patients (66.0%): in 20 children, within the first 12 months after surgery, and in 15, after more than 12 months. No recurrence was documented in the available medical records for 18 patients during the observation period. No statistically significant effect of the surgical treatment method on the recurrence rate (p = 0.813) or the risk of early recurrence (p = 0.926) was found. Also, no significant association was found between the child’s age and either the overall recurrence rate (p = 0.510) or the likelihood of early recurrence (p = 0.217). Conclusions. Within the limitations of this retrospective single-center study, neither the surgical treatment method nor the patient’s age was associated with clinically documented recurrence or early recurrence recorded in the available medical records.