Stem Cell-based Strategies to Improve Outcomes in Kidney Transplantation: A Bibliometric Analysis

2026

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DOI 10.4103/wkrj.wkrj_38_26
Data confidence 70 medium
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Abstract

A BSTRACT Background: The long-term survival of a kidney transplant is still limited by ischemic reperfusion injury, rejection, and other factors. Stem cell-based regeneration approaches are increasingly being explored as strategies to improve transplant outcomes. Objective: To map the modern scientific landscape of research, the relationship between stem cells and kidney transplantation, identify leading authors, models of collaboration, and the impact of citations. Materials and Methods: Bibliometric analysis was performed on the basis of a deduplicated dataset provided as a combined export “Combinedabs.xlsx.” The final corpus contained 474 entries for 2022–2026. Results: The corpus included 474 documents, 3344 authors from 62 countries, and totaled 4784 citations. The peak of scientific work occurred in 2024, while 25 entries were published in 2026. Articles (50.6%) and reviews (37.6%) predominated, and publications in English accounted for 96.6% of the total corpus. Frontiers in Immunology magazine became the most productive (40 articles), and the USA led the national issue (153 articles). The keyword analysis identified kidney transplantation, mesenchymal stem cells, extracellular vesicles, immunosuppression, tolerance, and ischemic reperfusion injury as the main topics. Conclusions: The literature found reflects the recent interdisciplinary stage of research at the intersection of transplantation, immunology, and regenerative medicine. The field of research is shifting from broad immunological and descriptive research to translational interest in stem cells, extracellular vesicles, immunoengineering, and bioengineering platforms. However, the evidence base remains fragmented, and the breadth of the search strategy covers both research directly related to transplantation and related topics related to kidney regeneration.