Antibacterial Potential of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Against Clostridium Perfringens: An Experimental In Vitro and In Silico Study.

Sirous Banafi, Mohammad Hossein Marhamatizadeh, Nader Tanideh, Ebrahim Rahimi, Afshin Zare, Ramazon Safarzoda Sharoffidin, Amin Tamadon

2026

Full text Open access: Green Metadata (CSL-JSON)

DOI 10.30476/ijms.2026.108710.4369

Data confidence 70 medium

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Abstract

Background: protein-protein docking. Methods: enzymes using ClusPro. OD600 values were compared across exosome concentrations using one-way analysis of variance (ANOVA) (P<0.05). Results: RNA polymerase and ATP synthase, and between cathelicidin and DNA gyrase, with lower but consistent docking scores for Annexin A1 across targets. Conclusion: interactions with key bacterial enzymes.