Isothiouronium salts and thienopyridines derived from 7-azacoumarin-3-carboxamides

Alexey Vladimirovich Trifonov, Nurbol Orynbasaruly Appazov, Aiym E. Tolegen, Lyudmila K. Kibardina, Michail A. Pudovik, Anna Pavlovna Lyubina, Alexandra D. Voloshina, Victor Vasil'evich Syakaev, Almir Sabirovich Gazizov, Rakhymzhan Turmanov

2 more authors

Elena Chugunova, Alexander Romanovich Burilov

2026

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DOI 10.71267/mencom.8020

Data confidence 70 medium

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Abstract

A series of isothiouronium salts were synthesized by reacting 5-chloromethyl-7-azacoumarin-3-carboxamides with thiourea. Alkaline hydrolysis of these salts led to a new family of substituted thieno[3,4-c]pyridines. The antitumor activity of the resulting compounds was assessed.