Synthesis, Structure, and Antitumor Activity of Heterocyclic 2-[4-(Dimethylamino)benzyl]-3-oxoisoindoline-4-carboxylates

Gulim K. Mukusheva, Roza I. Jalmakhanbetova, Zharkyn Zh. Zhumagaliyeva, Gulzhaukhar A. Toktarbay, Irina A. Kolesnik, Ekaterina A. Akishina, Evgenij A. Dikusar, Vladimir Ivanovich Potkin, Alexander L. Pushkarchuk, Tatiana I. Terpinskaya

3 more authors

Fedor Ivanovich Zubkov, Mikhail S. Grigoriev, Hongwei Zhou

Molecules, 2026

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.3390/molecules31091528

Data confidence 70 medium

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Abstract

In this study, the synthesis of a series of alkaloid analogs-isoxazole and isothiazole esters of 2-substituted 3-oxoindoline-4-carboxylic acid was performed. The target derivatives were obtained by the carbodiimide method. It was established that the studied esters have low cytotoxicity and are able to enhance the effect of the anticancer drug carboplatin, taken in low doses (0.5-5 μM), by up to 30%. Quantum chemical modeling of the obtained compounds and their conjugates with carboplatin was carried out to analyze the relationship between various calculated parameters and the observed biological effects.