QUALITY CONTROL OF INACTIVATED ASSOCIATED VACCINES AGAINST NEWCASTLE DISEASE AND BIRD FLU

T.I. Baiseit, Elina Kalimolda, Zharkinay Absatova, К.К. Джекебеков, S. U. Moldagulova

2024

Full text Open access: Hybrid Metadata (CSL-JSON)
DOI 10.58318/2957-5702-2023-16-6-17
Data confidence 85 high
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Abstract

The work contains the results of quality control of an experimental series of inactivated associated vaccine against Newcastle disease (ND) and avian influenza (AI) produced at the Research Institute for Biological Safety Problems of the Ministry of Health of the Republic of Kazakhstan. The purpose of the study was to test to determine the main indicators - the physicochemical properties of an experimental series of inactivated associated vaccine against BN and AI. The results of the experimental series showed that the vaccine is without contaminants, the concentration of hydrogen ions (pH) is 7.29 ± 0.0002137, the kinematic viscosity of the emulsion is 35.37 ± 0.00944, the vaccine is immunogenic for 12 month old chickens and harmless for chickens 30 days old . The average titers of antibodies to the virus on the 28th day after vaccination averaged 1:24.5 against the HP virus and 1:27.3 against the ND virus 1:24.5 in the hemagglutination inhibition test (HAI). The vaccine meets all the requirements in its physical and biological properties and is suitable for an associated vaccine against ND and AI. The vaccine meets all quality requirements according to the scientific and technical documentation of the manufacturer.