Abstract
Background: The relevance of this problem is determined by the high prevalence of obesity among older men. Studying the role of genetic variations of the Sex hormonebinding globulin and lipoprotein lipase transport proteins in the mechanisms of regulation of lipid metabolism is important for researchers investigating metabolic disorders. It also provides a basis for personalized strategies for the treatment and prevention of age-related hypogonadism. Materials and methods: The association between polymorphisms (rs727428, rs10822184) and lipoprotein lipase (rs754493647) and lipid metabolism disorders in overweight Kazakh men has been examined for the first time in a cohort of 235 Kazakh men residing in Semey city, Abai region. The main group included overweighed men with a body mass index of 25-29.9 kg/m2 (n=70), and the control group indicated a normal BMI of up to 25 kg/m2 (n=145). Genotyping of single nucleotide polymorphisms rs727428[C/T], rs10822184 [C/T], and rs75449364 [C/T] was performed by the TagMan method. Results: Polymorphism rs 10822184 demonstrated an increase in triglyceride and lipoprotein lipase levels in the TT genotype (p ≤ 0.04) compared to the CC and TT genotypes. An association was found between rs 727428 and albumin (p = 0.03) and testosterone (p = 0.001). Conclusions: In men of Kazakh ethnicity, triglyceride and lipoprotein lipase levels are associated with rs10822184, while rs727428 polymorphism is associated with total testosterone levels. In older men, a change in Sex hormone–binding globulin concentration is a predictor of lipid profile disorders.