Abstract
Introduction. Acute kidney injury in childhood is an actual issue due to its multiple causes, severity, and high risk of progression to chronic kidney disease. We can see that there is growing evidence of аcute kidney injury among children, because it is associated with high morbidity and mortality. It is a common condition in pediatric intensive care units, varying from 10 % to 35 % of cases. Recently, this problem has become increasingly important not only medically but also socially. Objective: To study the incidence of аcute kidney injury and its clinical and laboratory manifestations in children aged 1 to 17 years. Methods and Materials: This single-center retrospective study included 56 children aged 1 to 17 years with established acute kidney injury. The analysis was conducted using pediatric inpatient records from the Nephrology Department and the Intensive Care Unit of Children's City Clinical Hospital No. 2 in Almaty, from January 2022 to December 2023. Results. Acute kidney injury in 56 children was classified according to KDIGO (2012) as stage 0 in 17.8 % (10), stage 1 in 30.5 % (17), stage 2 in 12.5 % (7), and stage 3 in 39.2 % (22). The following main clinical and laboratory manifestations of acute kidney injury were identified: edema syndrome (37.5 %), predominantly localized to the lower extremities (62 %); hypertension syndrome (35.7 %); increased creatinine; decreased glomerular filtration rate; hyperazotemia; increased C-reactive protein; proteinuria; and leukocyturia. Conclusions. For the early detection of acute kidney injury and timely assessment of the severity of children's condition, it is recommended to use the Kidney Disease: Improving Global Outcomes classification (2012). Children who have had an episode of acute kidney injury stages 1, 2, and 3 should be considered at group risk for developing chronic kidney disease.