Abstract 126: Kazakh ThromboTest For Thrombosis Risk In Stent‐Assisted Cerebral Aneurysm Treatment

Mynzhylky Berdikhojayev, A Maidan

Stroke Vascular and Interventional Neurology, 2025

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DOI 10.1161/svi270000_126
Data confidence 70 medium
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Abstract

Introduction/Purpose Endovascular approaches such as stent‐assisted coiling and flow diverter placement have greatly expanded treatment options for complex cerebral aneurysms, yet intraoperative thrombotic complications remain a major concern. Standard platelet function tests are often limited in predicting real‐time thrombotic risk during procedures. This study aimed to evaluate the clinical utility of the Kazakh ThromboTest (KTT) for intraoperative thrombosis risk assessment in patients undergoing stent‐assisted treatment of cerebral aneurysms. Materials/Methods We conducted a single‐center observational study of 284 patients (208 females; mean age 57 years) who underwent stent‐assisted coiling or flow diverter placement for cerebral aneurysms. The KTT was applied intraoperatively to evaluate platelet aggregation and thrombotic risk in real time. Device deployment and angiographic control at 7‐15 minutes were used as benchmarks for procedural success and correlation with test results. Outcomes assessed included successful deployment, intraoperative thrombotic events, and angiographic confirmation of vessel patency. Results KTT was successfully performed in all 284 procedures, yielding positive results in 8 patients (2.8%) and negative results in 276 patients (97.2%). In patients with positive KTT findings, intraoperative optimization was implemented, most often through balloon‐assisted techniques combined with antiplatelet adjustment. Successful deployment of the stent or flow diverter with confirmed vessel patency was achieved in all patients. Control angiography at 7‐15 minutes consistently corroborated KTT predictions, and no intraoperative device occlusions were observed. Conclusion The Kazakh ThromboTest provides a rapid and reliable intraoperative method for thrombosis risk assessment during both stent‐assisted coiling and flow diverter treatment of cerebral aneurysms. Its predictive value for thromboembolic events and ability to guide real‐time antiplatelet management may enhance procedural safety. These findings suggest that KTT has potential as a practical adjunct in endovascular neurosurgery, warranting larger prospective validation studies.