Abstract
Introduction Due to the specific work content, healthcare workers (HCWs) showed a high risk of mental health and well-being issues. And the COVID-19 pandemic has increased this effect. At the same time, the psychological well-being of HCWs from Central Asian countries remains poorly understood. In this study, we aimed to investigate the mental health and well-being of HCWs from Central Asian countries, as well as associated factors, including the role of the impact of the COVID-19 Pandemic. Methods A cross-sectional questioner-based study was carried out among HCWs from Central Asian countries during the July-November, 2022. The study included socio-demographic questions, DASS-21 scale, WHO-5 Well-being Index, and questions to assess the impact of COVID-19 on personal life and work of HCWs. Results The study involved 2,685 HCWs from the Kazakhstan (1,817), Kyrgyzstan (534), and Uzbekistan (334). The overall prevalence of depression, anxiety and stress was 17.7%, 24.9% and 5.2%, respectively. Socio-demographic factors such as gender, age, marital and family status, occupation, managerial position; as well as pandemic-related frontline work history and changes in work and social life were associated with mental health and well-being. Conclusion The study underscores the pressing need to address the mental health challenges faced by HCWs in Central Asia, exacerbated by the COVID-19 pandemic. Findings reveal concerning levels of depression, anxiety, and stress among HCWs, with socio-demographic factors and pandemic-related experiences influencing mental well-being. Urgent interventions, tailored support, and resources are essential to safeguard the psychological health of HCWs and sustain effective healthcare delivery.