Effect of Photodynamic therapy on the Expression Toll-like receptors 2/3/4/8 in the HPV-related cervical lesions

Alexander D. Dushkin, Maxim S. Afanasiev, Т. Г. Гришачева, Stanislav S. Afanasiev, О. А. Свитич, Biryukova Elena, Akmaral Khangeldi, Alexander Viktorovich Karaulov

2025

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1016/j.pdpdt.2025.104899

Data confidence 70 medium

How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

Significance The first obstacle to human papillomavirus (HPV) is Toll-like receptors (TLRs). Research has revealed that TLR signaling demonstrating both tumor-suppressive and tumor-promoting effects Approach 2-ddCt value of m RNA TLR2, 3, 4 and 8 expressions after PDT in 121 women with HPV-related cervical lesions. Results TLR8 showed the most consistent reduction across all groups with the strongest suppression in cervical cancer cases. Conclusions TLR8 has the potential to serve as a novel earlier molecular immunological marker for the progression of HPV infection. TLR4 may represent an additional marker due to its reduced expression after PDT in cervical cancer.