One More Opportunity in Early-Stage Cervical Cancer: The Role of Photodynamic therapy in Managing Positive Surgical Margins

Maxim S. Afanasiev, Alexander D. Dushkin, Т. Г. Гришачева, Stanislav S. Afanasiev, Irina Dushkina, Akmaral Khangeldi, Nasrulla Abdullaevich Shanazarov, Alexander Viktorovich Karaulov

Photodiagnosis and Photodynamic Therapy, 2025

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1016/j.pdpdt.2025.104919

Data confidence 70 medium

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Abstract

Significance The investigation into the role of photodynamic therapy (PDT) in treating early cervical cancer, both as a primary modality and as an adjuvant for positive surgical margins, is of paramount significance and clinical relevance. Approach This study evaluates the recurrence of SILs and HPV infection in a cohort of patients with early-stage cervical cancer treated by PDT. Results The better result of PDT was achieved in the group of patients with partial response after PDT (more than 90%) for both study groups. This demonstrates that PDT based on chlorin e6 is highly effective to remove SILs or residual tumors. Conclusions This research holds the promise of transforming management strategies, offering a less invasive, fertility-sparing, and highly effective treatment option that could profoundly improve outcomes and quality of life for countless women worldwide.