Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells

Irina Savitskaya, Dina Shokatayeva, Aida Kistaubayeva, Lyudmila V. Ignatova, Ilya Digel, Aizhan B. Talipova

Heliyon, 2019

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1016/j.heliyon.2019.e02592

Data confidence 85 high

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Abstract

A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (10 10 /g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis , Escherichia coli, Pseudomonas aeruginosa . Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product.