Abstract
Introduction. The search for new and effective plant growth stimulants and chemical plant protection agents remains a pressing issue in modern agrochemistry. This study aimed to synthesize dithiocarbamate and its thioanhidrides based on pyrrolidin-2-one and evaluate their potential as plant growth regulators, herbicides and fungicides. Results and Discussion: Sodium dithiocarbamate based on 2-oxopyrrolidine and its butyric and benzoic 2-oxopyrrolidine-1-carbothioic thioanhydrides was synthesized with yields of 84%, 88%, and 67%, respectively. The structures of the synthesized compounds were established based on the analysis of elemental data, IR spectroscopy, 1H and 13C NMR spectroscopy data. Primary laboratory screening for growth-stimulating, herbicidal, and fungicidal activity was carried out. Conclusion: High germination rates were observed when wheat seeds were treated with sodium 2-oxopyrrolidine-1-carbodithioate at a concentration of 100 mg/l, resulting in 90% laboratory germination compared to 70% in the control and 80% with treatment by the standards KN-2 and AN-16. Phytotoxicity assays demonstrated that compound 1, at concentrations of 0.01-1 mg/ml, did not negatively affect the sowing qualities of Agrostis and Lactuca seeds and instead promoted intensive growth. Furthermore, sodium dithiocarbamate and its thioanhdrides exhibited fungicidal activity comparable to the standard tetramethylthiuram disulfide (TMTD). The infection rate of wheat and barley seeds by phytopathogenic fungi in the untreated control was 100% and 77.3%, respectively. In contrast, treatment with compounds 1-3 at 0.001-0.1% reduced infection to 12.6-26% for wheat and 7.3-16% for barley, compared to 0.4% and 2.6% with TMTD.