Resistance of microorganisms isolated from patients with COVID-19

Saule Maukayeva

2025

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DOI 10.54500/2790-1203-2025-2-125-50-55
Data confidence 70 medium
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Abstract

The rational use of antibiotics plays a crucial role in slowing the spread of resistant strains of pathogens. Excessive use of antibiotics, combined with reduced surveillance capabilities for the formation of antibiotic-resistant microorganisms, may lead to an increase in antibiotic resistance as a long-term consequence of the COVID-19 pandemic. The study of antibiotic resistance of microbes will allow the rational use of antibacterial drugs. The aim of the study was to study the antibiotic resistance of pathogens isolated from the respiratory tract in patients with confirmed COVID–19 in the period from 2020 to 2022. Methods. A retrospective study was conducted on the medical records of patients undergoing inpatient treatment with a diagnosis of COVID-19 in 2020-2022. The antibioticogram was presented by the following groups of antibacterial drugs: Gentamicin, Ceftriaxone, Amoxiclav, Ofloxacin, Cefazolin, Cefuroxime, Cefoperazone.Results. Candida, S.Pneumoniae, S.Haemolyticus, S.Pyogenes, S.Aegeis, Ps.Aeruginosae were isolated in the structure of pathogens obtained from patients with coronavirus infection. The highest sensitivity to antibiotics was found in gentamicin 53 (70.7%), slightly less than 37 (49.3%) in ceftriaxone, sensitivity to amoxiclav was detected in 26 (34.7%) cases. The lowest sensitivity was found to cefoperazone 7 (9.3%). Statistically significant antibiotic sensitivity to Candida 10*6, S.Pneumoniae 10*6, S.Haemolyticus 10*7, S.Pyogenes 10*7 was revealed. There was no statistically significant sensitivity to S.Aegeis 10*5, Ps.Aeruginosae 10*6 of any of the antibiotics used. Conclusions. The results of a retrospective study confirmed the need for microbiological monitoring of pathogens affecting the respiratory tract and changes in the tactics of antibiotic therapy based on an assessment of the antibioticogram of the microorganisms prevalent in the region isolated during COVID-19.Keywords: antibiotic resistance, coronavirus infection.