Weight Loss in Patients With Treated Type Two Diabetes, Diabetic Nephropathy, Hypertension, and Metabolic-Associated Steatohepatitis: A Randomized Clinical Trial

Kuat Oshakbayev, Alisher Idrisov, Altay Nabiyev, Kenzhekyz Manekenova, Gani Kuttymaratov, Gulnur Daniyarova, Bibazhar Abayevna Dukenbayeva

Current Developments in Nutrition, 2025

Full text Open access: Gold Metadata (CSL-JSON)

DOI 10.1016/j.cdnut.2025.106066

Data confidence 70 medium

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Abstract

and mental health by using a standard Likert scale of EORTC QLQ C30 (version 3).Results: After 6 months, the CRC stage (p ¼ 0.017), body weight (p ¼ 0.017) and HC (p ¼ 0.04) were significantly associated with QoL.This was consistent with the physical, role, and cognitive functional scales, all worsening with older adults.Role function (p ¼ 0.002) and emotional function (p ¼ 0.032) weakened in patients with chronic stage of CRC.Poor body weight (p ¼ 0.001) and low BMI (p ¼ 0.014) were specifically associated with low role and cognitive function, while low HC (p ¼ 0.043) was associated with low emotional function.Insomnia (p ¼ 0.048) was significantly associated with chronic CRC stage while older adults (p ¼ 0.006) had a significantly higher pain scale.Conclusions: The nutritional factors identified in this study should help health professionals and loved ones develop a plan for improving QoL in CRC patients.