Esterification of Many Drugs Causes Its Prolonged Action Due to Increase Lipid Solubility and Store in Fatty Tissues

2025

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DOI 10.56397/crms.2025.03.02
Data confidence 70 medium
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Abstract

The esterification process is a reaction between alcohol and acid which increases the resistance to metabolism, increases lipid solubility, and takes time to liberate the active constituent either alcohol or acid. Fluphenazine is an antipsychotic drug that is in the form of decanoate which is prolonged in its action making it take 1 month. Nandrolone decanoate, progesterone acetate, propionate and cypionate, also benzathine and penicillin procaine.