Features of the distribution of the obesity phenotype depending on age

Н.Т. Аблайханова, I. M. Okhas, Z. Tolebayeva, Arailym Yessenbekova, Beibarys Mukhitdin, B. A. Ussipbek, Ayauly Duisenbek, Л.С. Кожамжарова

2025

Closed access Metadata (CSL-JSON)
DOI 10.31489/2025bmg1/113-121
Data confidence 70 medium
How this score is calculated

It is built from checkable properties of the record itself: whether the article has a DOI, how many independent sources confirmed its data, whether the required fields are filled in, and how recent the latest confirmation is. Disagreement between sources and a missing identifier lower it. A value of 80 or above means the record was published without further checking; 60 to 79 means it is published at reduced confidence, with a manual check advisable. A record verified by an editor by hand is never pushed below 90 by a recalculation. This scores our data about the article, not the article itself.

Abstract

The article analyzes the prevalence of the metabolically healthy obesity (MHO) phenotype concerning age and gender. Similar to global studies, the criteria for this phenotype are actively being investigated in Kazakhstan. In 2017, the Kazakhstan Cardiology Center (KCC) presented a draft of recommendations regarding obesity. A key question revolves around the feasibility of classifying patients with metabolically healthy obesity phenotypes. It has been suggested that phenotype should be defined for each body mass index (BMI) group based on the waist-to-hip ratio. The findings indicate that the frequency of metabolic syndrome varies significantly depending on the classification used. Among women, metabolically healthy obesity phenotype occurs more frequently than in men, though its prevalence decreases with age. Individuals with metabolic syndrome, an increase in mean arterial pressure while maintaining normal levels of cholesterol, triglycerides, and high-density lipoproteins, regardless of the classification used. When using the KCC criteria to define MHO, the frequency of cardiometabolic risk factors was higher compared to other criteria. The conducted study revealed variability in the frequency of metabolic syndrome depending on the criteria used for classification: International Diabetes Federation (IDF) (2021) — 23.2 %, KCC (2021) — 27.1 %, NCEP ATP III (2021) — 41.8 %. Depending on age, the frequency of MHO phenotype in menopausal women showed a sta[1]tistically significant increase across all classifications. A notable decline in the prevalence of is observed in statistical indicators among women over the age of 55.