Polymorphism of the NIPAL1 Gene rs135173498 as a Marker of Embryonic Lethality in Auliekol Cattle

Alena Valentinovna Belaya, E. A. Klimanova, Норкина Виолетта Михайловна, Индира Бейшова

2025

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DOI 10.1134/s1022795424701394
Data confidence 70 medium
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Abstract

Abstract—It was found that, in Auliekol cattle, SNP G/A rs135173498 associated with live weight at birth (p‑value = 2.71E-06) is characterized by the absence of live-born calves homozygous for the rare genotype with a significant sample size of 497 animals. At the same time, calves with a heterozygous genotype were not characterized by a decrease in live weight at birth relative to the values of this indicator for the sample as a whole. The article analyzes possible mechanisms for the development of the phenotypic effect of SNP rs135173498 of the NIPAL1 gene as a factor of embryonic lethality in Auliekol cattle, and, presumably, in the Kazakh Whiteheaded, Aberdeen Angus, and Charolais breeds.