Abstract
The aim of the study is the synthesis of heterocyclic derivatives of alkaloids. A convenient method has been developed for obtaining natural alkaloid derivatives of anabazine and cytisine by the acylation reaction of 1,2-azole-3-, pyridine-3-, pyridine-4- and adamantane-1-carbonyl chlorides. A number of N-acyl derivatives of anabazine and cytisine have been obtained for the discovery of new medicines based on natural products. Molecular docking of the studied compounds was carried out on a model of hemagglutinin (1 RAY 1930 Swine H1 Hemagglutinin) and neuraminidase (neuraminidase 3BEQ strain A/Brevig Mission/1/1918 H1N1) proteins. It was found that all the studied compounds are able to bind to hemagglutinin and neuraminidase. Computer modeling was carried out on the basis of the AutoDock Vina 1.1.2 program, as well as external tools such as AutoDock Tools. All synthesized compounds were tested for antiviral activity. Compounds with adamantane fragment showed the greatest antiviral effect. Adamantane derivatives of anabazine and cytisine showed pronounced antiviral properties, even surpassing the commercial drugs Tamiflu and Remantadine in activity. Derivatives of N-acyl anabazine and cytisine are promising for further study of their pharmacological properties.