Abstract
The sulfa drugs are bacteriostatic when used side effects appear as a decrease in blood glucose level which led us to oral hypoglycemics (Sulfonylurea drugs), and diuretic action which led us to diuretics (Thiazide drugs), these side effects attention us to the discovery of diuretics and oral hypoglycemics. Sulfonamides are synthetic antibacterial which were the first antibacterial compounds till the presence of Penicillins, the sulfonamides are used as urinary tract infection treatment and treatment of certain forms of malaria and prevent infection of burns, the sulfa drugs act via inhibition of di hydro folate reductase enzyme (DHFR), they act by interfering with synthesis of folic acid which is vitamin B9 (Member of Vit. B complex) which required by all living cells.