Abstract
The study aimed to examine the nature and characteristics of intestinal dysbiosis in patients with pancreatic and biliary system diseases, with the presence of hyperosmolar diarrhea, in the clinical setting, and to evaluate the efficacy of probiotics as part of the treatment regimen. A two-stage retrospective descriptive and prospective randomized controlled trial was performed at the NpJSC Astana Medical University. The first stage was the clinical assessment of the intestinal microbiocenosis of patients with diseases of the pancreato-biliary system with the presence of hyperosmolar diarrhea. In total, 284 medical records were analyzed. The second stage was a prospective randomized controlled trial conducted to compare the efficacy of probiotics Biovestin-Lacto (contains strains of Bifidobacterium bifidum, B. adolescentis and Lactobacillus plantarum) and Normobact Forte (contains the strain L. rhamnosus). The study found that in patients with diseases of the pancreato-biliary system with the presence of hyperosmolar diarrhea, dysbiotic changes of the intestinal microbiota are unidirectional. This probiotic stimulated the indigenous microflora and reduced the growth of opportunistic bacteria and yeast-like fungi.