Abstract
A short theory of the processes of formation of the laser speckle fields polarization structure of biological tissues with optically anisotropic architectonics is presented. A method of polarization interference mapping of speckle fields with layerby-layer phase scanning of holographically reconstructed distributions of complex amplitudes of biological preparations of various morphological structures and physiological states has been proposed and experimentally tested - biopsies of the thyroid gland and blood films of rats with different severity of sepsis. Layer-by-layer maps of polarization ellipticity of native histological sections of thyroid biopsies from donors and sick patients were studied. As part of the statistical analysis of phase coordinate distributions of polarization ellipticity, objective markers for the differential diagnosis of thyroid pathology were found - nodular goiter, autoimmune thyroiditis and papillary cancer. Very good (~90%) and excellent (≥90%) accuracy of differential diagnosis was achieved. Statistical markers for temporal monitoring of septic changes in polarization azimuth maps of polycrystalline blood films of rats were found. An example of further research using laser-induced autofluorescence polarimetry methods is presented.