Аннотация
Introduction: It is known that mitosis is a fundamental process and it has been researched in normal as well as in pathology.It is suggested that the cause of a colossal number of research about mitosis is an empirical approach to the problem.For example, finding the optimal combination (MF) of only nine components (cytokines or any proteins) requires 181440 steps.Aim: In the study, the aging-related approach to detection of an explicit of mitotic factor MF to control mitosis through only one step is offered. Material and Methods:The following formula of MF has been invented: MF = ∆ (A-B).The formula includes: (a) Composition of the known components of thoracic duct lymph (TDL) of immature rabbits and (b) composition of the known components of mature rabbits TDL, ∆ -the difference of the components composition between "A" and "B." Results and Discussion: The approach should be carried out in the following succession: (1) To obtain samples of TDL of immature rabbits and TDL of mature rabbits (groups 1-"A" and 2-"B" accordingly) by special glass micropipette (Patent № 1495076, Russia), (2) to make lymph plasma from the samples of TDL of rabbits of group 1 and group 2, (3) to find a qualitative and quantitative components composition of lymph plasma and TDL cells of group 1 and group 2, and (4) to find the difference (MF/∆) between the lymph plasma of the components composition of groups 1 and 2. Consequently, the difference (∆) will be the sought-for MF.To study MF proteomic analysis can be used. Conclusions:The aging-related approach can be used to study different features of TDL, particularly cells division, identification of lymph MF, that can play a key role in access to cell dividing mechanism, and it is the way to elaborate new cancer drugs.