Аннотация
Aim SARS-CoV-2 infection is associated with an increased risk of preterm birth, preeclampsia and stillbirth. Therefore, women planning pregnancy during the pandemic should have been recommended to be vaccinated against COVID-19. The objective of this study was to evaluate the impact of pre-pregnancy and asymptomatic COVID-19 infection during pregnancy, as well as vaccination, on preterm birth during the pandemic.Material and Method This retrospective study included clinical records of women vaccinated before pregnancy. All women were SARS-Cov-2 PCR-negative at the time of birth and did not have a history of PCR-confirmed COVID-19. The asymptomatic transmission of COVID-19 was determined by the presence of antibodies to the N-antigen (N+S+), the presence of vaccination was determined by anamnesis and confirmed by the presence of antibodies only to the S-antigen (N-S+).Results From 113 vaccinated women with no history of PCR-confirmed COVID-19, 46 (40%) had antibodies to the N antigen of SARS-Cov-2. Preterm birth was significantly more common in women over 40 years of age (p=0.005), with preeclampsia (p=0.006) and with intrauterine growth retardation (p=0.016). To assess the impact of vaccination, 2 study groups (1 - those who had COVID-19 asymptomatically or in an unexpressed form and 2 - those who were vaccinated against COVID-19 and did not have the disease) were formed. No significant differences were found between groups in terms of the incidence of premature births (43% and 37%, respectively, p>0.05).Conclusions Maternal Covid-19 vaccination carried out before pregnancy did not have any negative effect on the premature birth rates.