Аннотация
Abstract. Introduction. Literature analysis is presented showing the existence of both phylogenetic and functional interrelation of internal diseases and oral-cavity diseases. Comorbidities contribute to the patients’ longer stay in hospital, reduce the quality of measures taken to prevent disabilities, and increase the number of post-surgical complications. Aim of the study is a review of the current information on the functional relationship between internal diseases and oral-cavity diseases. Material and Methods. Published topical studies were studied that deal with investigating the mechanisms of the relationship between oral infections and secondary systemic manifestations. Results and Discussion. Data are presented on the pathogenetic unity of the occurrences of somatic and dental diseases. Causal relationships are substantiated between them, arising from the impaired immunologic balance, interleukin regulation, and nonspecific resistance in human body. We noticed the negative comorbidity of internal and oral-cavity diseases, namely, the dependence of dental diseases on the general body condition and the influence of chronic infection foci in the oral cavity on the development of common diseases. Odontogenic transient bacteremia was proven at the dentist’s office, and conditions are shown for its transformation into any infectious disease. We identified the need for unified systemic approaches to the treatment of polymorbid pathology. Conclusions. Influence of comorbid pathology on clinical manifestations, diagnoses, prognoses, and treatment of many diseases is multifaceted and individual.