Аннотация
The liver is the central organ of detoxification and metabolism and is most susceptible to the toxic effects of products of malignant growth. Therefore, the effectiveness of lymphatic drainage of the organ plays an important role in maintaining homeostasis of the whole organism. The aim of the study was to identify structural changes in the lymphatic drainage of the liver during the development of experimental hepatocacinoma-29 in the muscle tissue of the thigh of CBA mice. Using light, electron microscopy and immunohistochemistry, we studied the structure of various parts of the lymphatic drainage of the liver under conditions of the development of hepatocarcinoma-29 in the muscular tissue of the thigh of CBA animals. It was revealed that under conditions of distant tumor growth, structural changes develop in the liver: a decrease in the volume and numerical density of hepatocytes, an increase in the volume density of sinusoidal spaces, an increase in the size of liver prelimfatiks — Dissa spaces, an increase in the sinusoidal endothelial cells, an increase in the lumens of the lymph vessels of the portal tracts. The observed structural changes in various parts of the lymphatic drainage of the liver under conditions of remote tumor growth indicate an increase in lymphatic processes associated with the presence of toxic metabolites in the blood.