Аннотация
This literature review covers the topic of nervous system disorders caused by defects in copper metabolism in brain tissue. The role and participation of this element in many physiological functions of the central nervous system in normal and pathological conditions are identified and described. Neurodegenerative disorders in which there is an accumulation of "free" copper in the brain tissue are considered (Alzheimer’s, Wilson, Menkes). Genetic diseases caused by excessive or insufficient copper intake in the brain tissue, which manifest as neurological disorders, are described. Particular attention is paid to the features of copper metabolism in brain tissue with neurological disorders. This direction is also complemented by a description of pathological changes during the deposition of copper in the nervous system. The article reveals the mechanisms of toxicological effects in case of excessive intake of copper in the nervous tissue of experimental animals.