Аннотация
The aim of this study is to study the role of platelet-rich plasma (PRP) on the healing of ureteroneocystostomy (UCA) in a rabbit model. Methods: A total of 14 adult male New Zealand rabbits (Oryctolagus cuniculus) were divided into two groups: group I (n=7), standard anastomosis without PRP; group II (n=7), standard anastomosis with PRP. The animals were observed for 7 days, then killed. The parameters of the study were complications of anastomosis, evaluation of hydroxyproline and histopathological evaluation of anastomoses. Results: The level of hydroxyproline was statistically higher in the PRP group than in the control group (P<0.05). Histological evaluation of the anastomoses showed almost complete healing in all animals. The average histological parameters of the animals in the groups did not differ. Conclusions: According to our results, we assume that the use of PRP improves the healing of the anastomosis due to the level of hydroxyproline and a decrease in the inflammatory response. Further clinical studies are needed to confirm our hypothesis.