Аннотация
Study of the effect of natural polyphenols on the prostate cancer Du145 cells' cycleRelevance: Although natural polyphenols are known as useful nutrients, their use is quite occasional.This is probably due to a lack of complete information on their biochemical structure and mechanism of action.Scientific literature offers many studies on polyphenols' benefits and metabolic effects on the body.Polyphenols are known to improve body function and increase physiological activity.Polyphenols are used in the body's normal physiological function and metabolic disorders, and their therapeutic effect can be controlled in complex pathological conditions.Therefore, in our study, we used curcumin and carnosic acid to control the natural polyphenols' metabolic effects' structure and function in prostate cancer.Metabolic disorders in mitochondria, one of the organelles responsible for cell energy metabolism, have an irreversible effect on the cell, organ, and the system as a whole.This urges the study of cellular action on individual organelles, including the biochemical and physiological aspects.The study aimed to determine the effect of natural polyphenols -curcumin and carnosic acid -on the prostate cancer cell cycle.Results: Combination of curcumin and carnosic acid caused a time-dependent exposure suppression of Du145 cancer cells growth at G 0/1 and S phases.Conclusions: The effect of natural polyphenols -curcumin and carnosic acid -on the Du145 prostate cancer cell cycle was determined.Curcumin 7μM and carnosic acid 10μM in combination stopped phases G 0/1 and S' prostate cancer cells division.