Аннотация
The influence of metabolic, molecular genetic- and immune-inflammatory factors on the course of reparative osteogenesis and the formation of bone nonunion of long bones is investigated on the basis of computer statistical analysis and forecasting methods. It has been established that hyperhomocysteinemia, dyslipidemia and cytokine imbalance are negative regressors of the structural and functional state of bone tissue, leading to increased levels of bone resorption markers and the development of systemic and local osteoporosis. The genetic determinants of the course of reparative osteogenesis in a hypoplastic and atrophic type are the homozygous carrier of mutations MTHFR C677T or eNOS T786S, as well as a combination of both polymorphisms.