Аннотация
Dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is the key enzyme regulating the breakdown of fluoropyrimidines (FPs). Variants in DPYD substantially alter DPD function and are firmly established predictors of FP-related adverse reactions. Four specific DPYD polymorphisms—rs3918290, rs55886062, rs67376798, and rs75017182—are incorporated into genotype-guided FP dosing recommendations and are advised by the European Medicines Agency (EMA) for testing prior to therapy. In Greece,