Аннотация
Uncontrolled asthma poses a widespread problem in Russia, fueled by the overuse of short-acting β 2 -agonists (SABA). The aim of the study titled “Clinical and demographic profiles of patients with uncontrolled asthma in Russia: multi-center observational registry study (ICEBERG)” is to investigate the clinical and demographic profile and treatment approaches in this patient population. Methods. An interim analysis of data from 2,024 adult patients with mild to moderate uncontrolled asthma was conducted. This multicenter observational retrospective-prospective study included two visits: baseline (collecting 52-week retrospective data and current status) and a 12-week follow-up visit to assess changes in therapy and clinical outcomes. Asthma control was assessed using Global Initiative for Asthma (GINA) criteria and the Asthma Control Questionnaire-5 (ACQ-5). Results. Patients with uncontrolled asthma predominantly exhibited a T2-high phenotype. A marked shift from SABA therapy to controller regimens was observed following the confirmation of uncontrolled disease: the proportion of patients on MART doubled (from 9.5% to 20.4%). This treatment optimization led to improved asthma control (full or partial control achieved in 70.6% of patients) and a significant reduction in the frequency and duration of exacerbations. The use of SABA as primary therapy remained a key risk factor for severe exacerbations. Conclusion. The consistent implementation of GINA strategies, in particular the transition to fixed-dose ICS/SABA combination therapy, the use of the MART regimen, and triple therapy, makes it possible to significantly improve the asthma control and reduce the risk of exacerbations in real-world clinical practice.