Аннотация
This chapter focuses on delivery strategies and bioengineering approaches for MSC-derived extracellular vesicles. It evaluates different routes of administration, including systemic and local delivery, and their impact on biodistribution and efficacy. Biomaterial-assisted delivery systems such as hydrogels and scaffolds are discussed as strategies to enhance retention and targeting. The chapter also reviews engineering approaches for cargo loading and surface modification to improve therapeutic performance.