Аннотация
Relevance: Spinal metastases are a common complication of breast cancer, often leading to severe pain, vertebral instability, and reduced quality of life. Percutaneous vertebroplasty (PVP) is a widely used, minimally invasive palliative procedure that stabilizes affected vertebrae and alleviates pain. Meanwhile, interest in supportive nutritional approaches such as mare’s milk has increased because of its potential immunomodulatory and anti-inflammatory properties. However, evidence on combining freeze-dried mare’s milk with PVP in this patient population remains limited. This study aimed to evaluate the clinical effect of percutaneous vertebroplasty in combination with adjuvant therapy and radiotherapy in the treatment of osteolytic spinal metastases with pain syndrome in breast cancer. Materials and methods: From November 2023 to September 2025, nine patients with pain syndrome due to metastatic spinal lesions (five thoracic and eight lumbar) were treated at the Astana Multidisciplinary Medical Center. The mean patient age was 59.56 years. All patients underwent PVP via a bilateral transpedicular approach, followed by adjuvant systemic therapy and radiotherapy targeting vertebral metastases. We assessed outcomes using demographic and clinical data, the Numerical Rating Scale (NRS), the Oswestry Disability Index (ODI), serum beta-CrossLaps levels, and radiographic findings. Results: The mean NRS score decreased from 8.67 ± 0.50 preoperatively to 1.78 ± 0.83 six months after PVP. Additionally, the mean ODI score decreased from 74.07 ± 13.15 preoperatively to 31.87 ± 10.00 six months after VP. Patients included in the study experienced a significant reduction in pain intensity. Furthermore, imaging data showed that metastatic carcinoma in the vertebral body was successfully controlled. Conclusion: VP in combination with adjuvant therapy and radiation therapy is an effective treatment strategy for spinal metastases.