Аннотация
Introduction: Parasitic diseases in sheep reduce sheep-breeding productivity and decrease the economic efficiency of the industry. Our research aim was to study of the dynamics of clinical sings development in the manifestation of associated eimeriosis and esophagostomosis invasion, as well as concomitant immunodeficiency state in experimentally infested lambs, and to evaluate the efficiency of complex treatment approach for associated invasions. Materials & Methods: A prospective study was conducted using helminthoscopic methods with the subsequent calculation of indicators of extensiveness and intensity of infestation, as well as haematological studies to determine of subpopulations of T- and B-lymphocytes.Results: Due to the more active development of protozoa, the main symptoms of associated invasion were those typical for acute Eimeriosis. Progression of the disease was accompanied by an increase in the intensity of invasion both in relation to Eimeria and Esophagostomes. At the same time, in animals with the development of invasion, there was a decrease in the total number of leukocytes (up to 25%), including T- and B-lymphocytes, indicating a decrease in humoral defense of the lambs’ organism. On the 24th day after infection, an increase in the level of T-lymphocytes (by 0.8%) was noted, due to an increase in T-helpers (by 2.0%). For treatment of associated infestation, Sulfamonomethoxine in combinationwith niacid was used. The use of these drugs in recommended doses and according to the developed scheme reduced the intensity of Eimeriosis invasion by 97-98% and esophagostomosis by 100%. Conclusion: This study provides data on eimerioses and eimeriosis-esophagostomosis infestation in sheep. In describing eimerioses and helminthoses of sheep, the species composition, distribution, and seasonal age dynamics of infestation were determined. The developed method of treatment showed high therapeutic effect and can be recommended for use in all sheep farms of the Republic of Kazakhstan.