Аннотация
Relevance: The significance of necessary and harmful trace elements in regulating female reproductive function has been intensively investigated in recent years. There is increasing evidence that the pathophysiology of gynecological and metabolic illnesses is associated with disturbances in trace element homeostasis. The study aimed to assess the elemental status of women of reproductive age in the Aktobe region (Kazakhstan) and determine its relationship with age characteristics. Materials and methods: A cross-sectional study was conducted involving women aged 18-35 years (n = 281). Concentrations of trace elements (cadmium, cobalt, lead, copper, manganese, selenium, zinc, chromium, magnesium) were determined using atomic absorption spectrometry. Statistical analysis was performed using SPSS version 26.0. Normality of distribution was assessed using the Kolmogorov-Smirnov test; data are presented as median and interquartile range (Q1-Q3). The Mann-Whitney U test was used for intergroup comparisons. Participants were divided into two age groups: 18-25 years and 25-35 years. Correlation analysis was performed using Spearman’s rank correlation coefficient. Results: No statistically significant differences were found between age groups for most trace elements (cadmium, cobalt, lead, selenium, zinc, chromium, magnesium) (p > 0.05). However, significant differences were observed for copper and manganese: copper levels were 1.6 times higher in the second group (p < 0.001), and manganese levels were 2 times higher (p = 0.004). Correlation analysis revealed a moderate positive association between age and copper levels (r = 0.339; p < 0.001) and a weak positive association with manganese levels (r = 0.183; p = 0.002). Conclusion: Age-related changes in trace element status among women of reproductive age (25-35 years) are limited. Copper and manganese may be considered potential indicators reflecting age-related metabolic and biological characteristics. These findings highlight the need for further research into the role of trace elements in the regulation of women’s reproductive health.