Аннотация
Introduction. Oxygen heterocyclic compounds occupy an important place in modern organic and medical chemistry. Tetrahydropyran derivatives in particular are widely studied due to their structural diversity and biological activity. In this regard, the problem of agribilogy and phytochemistry is to determine the biological activity of propargyloxybenzoic acid, an oxygenated derivative of 2,2-dimethyltetrahydropyran-4 — on and propargylated salicylic acid in the grains of single and dicotyledonous plants by the reaction of Favorsky. The purpose and objectives of the work is to study the biological activity of seeds of single and dicotyledonous plants with the synthesis of a new oxygenated heterocyclic compound based on 2,2-dimethyltetrahydropyran-4-on and propargylated salicylic acid. Tasks obtaining the original compound by The Prince reaction, synthesizing a new derivative using the Favorsky reaction, and studying its biological activity. Conclusion (conclusions). The oxygen heterocycle 2,2-dimethyltetrahydropyran-4-on was obtained with dimethylvinyl-ethinylcarbinol in a sulfuric acid medium and using mercury sulfate as a catalyst, with a yield of 70% through the Prince reaction mechanism. By reacting the resulting 2,2-dimethyltetrahydropyran-4-on with the acetylene derivative of salicylic acid by the Favorsky reaction, the acetylene derivative of 2,2-dimethyltetrahydropyran-4-on was synthesized with a 57% yield of 2,2-propagyloxy benzoic acid. The physicochemical properties of the obtained oxygen heterocycle compounds were determined and studied by IR spectroscopy. According to the results of a study of the biological activity of 2,2-propagyloxy benzoic acid on single and dicotyledonous plant grains, it was found that it significantly inhibited the growth of dicotyledonous plants in high concentrations, and was effective as a growth stimulant for single dicotyledonous plants.