Аннотация
Introduction: The use of deep learning in the detection of prostate cancer (PCa) based on multiparametric MRI (mpMRI) data is one of the most controversial areas of development of this technology in medicine. Despite high international interest in such systems, the number of thematic studies in the Russian Federation remains limited. Objective: To describe the process of creating and validating a domestic medical decision support system (MDSS) designed to diagnose PCa based on mpMRI results using AI. Materials and methods: Data on patients with a confirmed diagnosis who underwent radical prostatectomy were collected both retrospectively and prospectively. The patient sample was formed between January 10, 2023 and May 1, 2025. T2- weighted images (T2-WI) and measured diffusion coefficient (MDC) data were used as working sequences. Data annotation was performed manually by three specialists with more than 10 years of experience in independently performing and analyzing MR data of patients with suspected PCa. During the study, four different architectures were tested to evaluate their effectiveness and determine the most suitable one for the tasks at hand. The following metrics were used to measure accuracy: sensitivity, specificity, accuracy, area under the ROC curve (AUC), and Dice score (DSC). Results: In accordance with the inclusion criteria, 441 studies performed on 19 different MRI scanners were collected. Validation of the most productive neural network architecture revealed the following indicators: accuracy — 73%, sensitivity — 71%, specificity — 71%, AUC — 0.70, DSC — 0.70. Discussion: The work presented by us is aimed at familiarizing specialists with the intermediate results of the development of the first national MDSS, implemented according to a strategy of avoiding the shortcomings present in the works of other teams. Conclusion: The results of testing the developed AI-based program for the detection and reconstruction of PCa on MRI images showed promising prospects for the domestic medical decision support system. To confirm the clinical applicability and effectiveness of the developed program, further multicenter studies are needed to assess its potential and feasibility for implementation in real clinical practice.