Аннотация
Annotation.The assessment of workers' health requires the development of scientific approaches to detect early changes in the body as a result of exposure to production factors.There is very little scientific literature on the effect of unfavourable toxic factors of titanium-magnesium production on the organism.Currently, the issues of prenosological diagnostics are becoming more relevant, and the methods are being actively developed.Tissue metabolism plays a major role in the formation of prenosological conditions.Chronic stressor influence of production factors cause changes in the regulation of blood circulation.We have studied the influence of toxic chemical substances Ust-Kamenogorsk Titanium-Magnesium Plant (UKTMP) on the organism of workers, namely on the indicators of the kallikrein-kinin system of workers of the main workshops depending on the length of service at this enterprise, we determined the level of kininogen and prekallikrein, the activity of kininase and kallikrein.It was revealed that workers under the influence of a complex of production factors on the organism have activation of indicators of the kallikrein-kinin system, the changes depend on the length of service and the workshop.Kinins are necessary products of vital activity, they are contained in all organs and tissues, fulfil the role of chemical regulators of local and general blood flow rate.Our studies are necessary for early detection of changes in the body of workers and comprehensive treatment procedures, can prevent the development of occupational diseases.