Аңдатпа
Modification of a recombinant gel based on angiogenin by adding dioxidin to its composition leads to a pronounced antimicrobial effect against the main pathogens of purulent-septic infections - Staphylococcus aureus, colostrum, late blight and E. coli. The purpose of this study: to study the antimicrobial, anti-inflammatory and wound healing effects of angiogenin gel in comparison with a modified version of this drug - dioxidin-angiogenin gel. Methods. The objects of research are natural recombinant human angiogenin gel and modified recombinant human angiogenin gel with dioxydine. Native angiogenin gel is intended for external use, contains recombinant human angiogenin at a concentration of 25 micrograms / ml, excipients-polyethylene oxide (filler) and sodium benzoate (preservative). Recombinant human angiogenin gel with modified dioxidin contains recombinant human angiogenin at a concentration of 25 micrograms/ml and 5% dioxidin, excipients – polyethylene oxide (filler) and sodium benzoate (preservative). The antimicrobial activity of the objects of study was studied by diffusion into agar. Reference strains from the Republican Collection of Microorganisms were used as test strains: gram-positive cocci-Staphylococcus aureus ATCC 25922; Pseudomonas aeruginosa ATCC 27853; gram-positive bacteria - Bacillus subtilis 8232 and gram-negative rods. The results of the study of the anti-inflammatory activity of angiogenin gel and modified dioxydin angiogenin gel, which gave positive results with local treatment. Conclusions. When modifying a gel based on recombinant angiogenin with the addition of a chemotherapeutic drug, dioxidin is used to treat staphylococcus, peristalsis, hay and E.coli, a pronounced antimicrobial effect is manifested.